Chronic Inflammation Could Lead to Prostate Cancer

Chronic Inflammation Could Lead to Prostate Cancer

InflammationAs if men didn’t have enough to worry when it came to their prostate health, now comes the latest news about how inflammation could be linked to prostate cancer. The latest research says that men who experience chronic inflammation in their non-cancerous tissues were twice as likely to develop prostate cancer when compared to those with little to no inflammation. The research study was organized and performed by researchers from Johns Hopkins Kimmel Cancer Center.

The Study

After examining the research, it was found that the actual link between prostate cancer and inflammation was more in men when they were in “high-grade prostate cancer,” which is when your Gleason score is between 7 and 10. The Gleason score is the way physicians are aware of the stage of prostate cancer in your body. There are five different grades of prostate cancer and the Gleason score allows doctors to determine how serious and dangerous the current level of prostate cancer. This high score gives the indication to researchers that there could be aggressive and rapidly growing prostate cancer within the body.

Researchers from the study have “shown in this observational study is a clear association between prostate inflammation and prostate cancer, although we can’t prove that inflammation is a cause of prostate cancer.” Elizabeth A. Platz is a Sc.D., M.P.H., and professor at the Department of Epidemiology at the Johns Hopkins University Bloomberg School of Public Health and the School of Medicine made that statement when presenting their findings.

This new information isn’t meant to be the new diagnostic tool for doctors as there is some belief that inflammation is something that is so widespread in men that it shouldn’t be used as a diagnostic tool. Despite that, the findings make researchers want to learn more about what causes prostate inflammation and what role it has in contributing to prostate cancer and even if the inflammation could be prevented.

Platz added that she felt “there will be strategies going forward for either preventing inflammation or intervening when it occurs.”

All the findings in the report were displayed in the April 18th edition of Cancer Epidemiology, Biomarkers & Prevention. The findings of the report were made after examining information of men being “treated” with a placebo at the Southwest Oncology Group’s Prostate Cancer Prevention Trial. The basis for this trial was to find whether the drug finasteride could be used by doctors as a way of preventing prostate cancer. They performed biopsies at the conclusion of the study to see if there were elevated levels of the prostate specific antigen, or PSA.

The specifics of the study saw the researches examine the benign tissues of 191 men with prostate cancer and another 209 men without cancer. Researchers examined the samples and the likelihood and the extent of immune cells in the tissues that show inflammation. Of those 191 men that had their cancerous tissue cells examined, 86.2 percent had at least one tissue sample showing signs of inflammation. Of those men who did not have prostate cancer, 78.2 percent had at least one tissue sample showing inflammation.

When examining the numbers of the research more closely, one can see a high correlation of inflammation and prostate cancer. In total, men who had at least one tissue sample showing chronic inflammation had a 1.78 higher chance of developing prostate cancer and a 2.24 higher chance of having an aggressive form of the cancer. Even with men who had low PSA levels, the association between the numbers remained similar.

Past Information

There have been countless studies performed in the past that examined the possible link between prostate cancer and inflammation, but those studies began their research with sampling tissues from the male body who had a reason to have a biopsy performed.  In explaining the difference between this study and the latest research, Platz said that her study was “designed to rule out the bias that would ordinarily exist between the way we detect prostate cancer and the presence of inflammation.”

Conclusion and Outcome

When a patient has a high PSA level, their amount of inflammation will go up with it. With higher levels of PSA, men will be biopsied more often than otherwise, and by simply performing more biopsies, prostate cancer would be developed and in many cases, can help to prevent fatalities. The increased amount of biopsies performed will help doctors find and diagnose prostate cancer in their patients regardless of inflammation was the cause or not. 

>Learn more about the prostate gland

>Learn more about prostate massages

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